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Shunting of apocrine sweat onto the epidermis is quantitatively altered in Prader-Willi syndrome.
Prader-Willi syndrome (PWS) is a genetic disorder characterized by delayed growth, muscular hypotonia, and obesity, with a characteristic appetite-suppressing profile and behavioral immaturity. The etiology of PWS is heterogeneous, with imprinting abnormalities of the 15q11-q13 region being the most widely accepted, but other abnormalities in the same region have been described in patients without imprinting defects. Swelling associated with apocrine sweating may be influenced by physical activity and may be an important adjunct to the erythematous rash that often accompanies imbalances in body water. Because the rash observed in PWS is a classic marker for the disorder, this study explores the sweat production rate and the volume of sweat excreted in PWS. Sweat was collected from the palms and soles of 10 PWS patients and 8 healthy individuals at the same time of day in a dark, thermoneutral environment. The samples were quantified for total protein and sodium content, and the volume was determined with a centrifugal filter device. Sweat excretion rate was not different between PWS and control subjects, but the volume of sweat produced per unit surface area was elevated in PWS, suggestive of shunting of apocrine sweat onto the epidermis. Given the total daily sodium loss expected from this increased absorption, the possibility of a sodium deficit in PWS warrants further investigation.Increased synthesis of gamma-glutamyltransferase by the rat glial cell line C6.
C6 glial cells, a frequently used rat glial cell line, were incubated in serum-free medium with added glutamine. The utilization of glutamine was increased about threefold in cells incubated for 3 days, while protein, DNA and total cell number increased only slightly. Glutamine removal from the culture medium induced a rapid fall in total glutamine level in cells. Adding back glutamine to the medium resulted in an increase in total glutamine content and in protein synthesis. These results show that C6 cells can synthesize glutamine de novo and incorporate it in proteins. The observed increase in gamma-glutamyltransferase (gamma-GTPase) activity
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Last December, a ransomware attack targeted over 100 companies in India, affecting more than 300 million devices. Total losses are still under estimated. The goal of the attackers was to hit both Indian government and companies.
This is according to a paper by Simson Garfinkel and Mike Hamburg. Simson Garfinkel is CEO of Kombat Security and Mike Hamburg is VP of Kombat Security. According to their analysis, the attack highlights the vulnerabilities of businesses that use outdated enterprise software.
“The attack on these Indian companies is actually a brilliant wake up call to Indian enterprises that they will need to look seriously at their enterprise software architecture, their use of outdated enterprise software which is known to be one of the biggest and most common attack vectors,” Garfinkel told VentureBeat in
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